Diagram showing the study design for interferon versus methotrexate in intermediate uveitis with macular edema. Evaluation of serum interferons in patients with agerelated macular. A report of three cases to describe treatment of chronic irvinegass. The aim of this study is to compare the effectiveness of bevacizumab. Sep 25, 20 interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. Interferon alfa for the treatment of neovascular agerelated macular degeneration agerelated macular degeneration amd is a progressive and degenerative disease of the retina, causing blood vessels to develop under the retina which eventually lead to visual impairment. Intron a interferon alfa2b injection, solution dailymed. Interferon alfa2b injection route description and brand. There has been recent interest in the use of systemic interferon alfa 2a treatment for choroidal neovascular membranes cnv.
Interferon alpha 2b in the treatment of uveitic cystoid. Pegasys, peginterferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Roferona interferon alfa 2a, recombinant is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli bacterium containing dna that codes for the human protein. Interferon alfa2b side effects, dosage, interactions. Clinical experience with interferon alfa2a for exudative. Clinical experience with interferon alfa2a for exudative age. Aug 27, 2011 well the interferon injection is given by subcutaneous mode, but the problem was that we were not getting the marks by which we can give see the markings and give the injection. It is not known whether interferon alfa 2a passes into breast milk. Ifn alfa2a was administered at an initial dose of 3 or 6 million iu depending on body weight per day subcutaneously. Oct 28, 20 to report the effect of subtenon injections of natural leukocyte interferon. The fermentation is carried out in a defined nutrient medium containing the antibiotic tetracycline hydrochloride at a concentration of 5 to 10 mgl. We identified 23 additional cases of naion during interferon alpha therapy.
Several fdaapproved drug labels may be available for peginterferon alfa2b. Interferons in ophthalmology current status and advancing. Find patient medical information for interferon alfa2a injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Indicated for metastatic renal cell carcinoma in combination with interferon alfa2a. To assess the efficacy of interferon ifn alpha2a in the treatment of postuveitic refractory macular edema me. Aidsinfo provides the following drug label solely as an example of the labels available for peginterferon alfa2b. Patients were randomized into either a therapy with interferon beta 44. Commonly reported side effects of interferon alfa2b include. Treatment of refractory cystoid macular edema with pegylated. A 66yearold man affected by dme, with glycated hemoglobin hba1c at 6. In study 6 n526, subjects received either roferona 6 miu three times a week for 12 weeks followed by 3 miu three times a week for 36 weeks or pegasys 180 mcg once weekly. To report the efficacy and safety of interferon ifn. Based on its antiinflammatory, antiproliferative, and antiangiogenic effects, systemic and subtenon interferon alpha has been employed in the treatment of a wide range of posterior segment problems with an inflammatory component such as. The average followup was 8 months range 511 months.
Peg interferon alfa2a is compared in a number studies. Interferon alpha 2b in the treatment of uveitic cystoid macular edema article in ocular immunology and inflammation 202. Interferon versus methotrexate in intermediate uveitis. The specific activity of interferon alfa2b, recombinant is approximately 2. The efficacy of interferon alfa2a was studied in patients with sight threatening posterior uveitis or retinal vasculitis. Interferon alfa2a, recombinant is a highly purified protein containing 165 amino acids, and it has an approximate molecular weight. Interferons medical clinical policy bulletins aetna. May 30, 2018 interferon alfa 2b is made from human proteins.
Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy. Pegylated interferon alphaassociated optic neuropathy. There is a black box warning for this drug as shown. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. This means that it is not known whether interferon alfa 2a will be harmful to an unborn baby. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Interferon alfa2a has been shown to be effective as an antiangiogenic agent for several systemic human angiogenic disorders and has shown antiangiogenic activity in the laboratory. Recent progress in the treatment of uveitic macular edema.
Objective to report the benefits and complications of subcutaneous interferon alfa2a therapy for hemangiomas in children design prospective nonrandomized trial setting tertiary care. Interferon alfa2b injection route side effects mayo clinic. To report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional therapy. Nineteen patiens 20 eyes with the exudative form of macular degeneration were treated with parenteral interferon alfa 2a. How does interferon alpha peyronies treatment work.
Therefore, the dose of zidovudine may need to be reduced by as much as 75%. Well known trade names include intron a interferon alfa2b and roferona interferon alfa2a. Interferon alfa2b is an immunological agent that is fda approved for the treatment of patients 18 years of age or older with hairy cell leukemia and indicated as adjuvant to surgical treatment in. Since 1993, ocular complications following interferon therapy have been reported mainly. Bevacizumab for nonocular indications medical clinical. Interferon alfa2a solution, reconstituted recon soln warnings. Interferon alfa for the treatment of neovascular agerelated. Pdf clinical experience of interferon alfa2a treatment for. Pharmacological therapy for macular degeneration study group. Interferon alpha injections have been used to treat peyronies patients. Color photographs and fluorescein angiograms were evaluated independently by two masked readers for change. Treatment with pegylated interferon alfa2a led to an improvement in cme in all eyes of seven included patients, with a mean decrease. Ibm micromedex along with its needed effects, a medicine may cause some unwanted effects.
Interferon alpha is the generic name for the trade name drugs intron a, roferona. Although not all of these side effects may occur, if they do occur they may need medical attention. Intron a 5ml diluent interferon alfa2b, recombinant. While this reaction may improve zidovudines effectiveness, it also may increase the risk of blood and liver toxicity. To perform a prospective pilot study to evaluate interferon alfa2a ifn alfa2a for the treatment of refractory cystoid macular edema cme in endogenous uveitis. The dose of interferon alfa2a actually given was 76 to 100 percent of that scheduled for 53 percent of the patients, 50 to 75 percent of that scheduled for 29 percent, and less than 50 percent of. It has been used in the treatment of hepatitis, solid tumors and hematologic malignancies. Jun 05, 2018 interferon treatment for hepatitis c would typically last 2448 weeks 612 months. Symptoms began 19 weeks after starting peginterferon alpha2a.
The combination of these medicines can cause birth. This medication can rarely cause or worsen serious rarely fatal medical conditions, including mentalmood conditions e. Interferon alfa2a is ineffective for patients with. Some claims have been made that interferons produce about an 1838% reduction in the rate of ms relapses. Interferon alpha2a for subfoveal neovascularization in age. The burden of cystoid macular edema among those with uveitis is considerable. Aetna considers bevacizumab avastin, bevacizumab awwb mvasi, and bevacizumabbvzr zirabev exp erimental and investigational for the treatment of the following nonocular indications not an all.
Nineteen patients completed therapy and have received adequate followup. There has been recent interest in the use of systemic interferon alfa2a treatment for choroidal neovascular membranes cnv. Interferon alpha2a for proliferative diabetic retinopathy. Nov 09, 2018 interferon alfa 2b can harm an unborn baby or cause a miscarriage. The current study is a prospective randomized clinical trial to determine the effect of interferon alpha2a on eyes with subfoveal subretinal neovascularization secondary to agerelated macular. Interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Here a pilot study is reported in which 10 patients with exudative age. Interferon alfa 2a provides no benefit as a treatment for choroidal neovascularization secondary to agerelated macular degeneration and may be associated with a poorer visual outcome when given at a dose of 6 miu. Interferon alfa2b should be used cautiously in patients with debilitating conditions such as those with a history of cardiac disease e. Interferons in ophthalmology current status and advancing trends. Topical interferon alpha 2b in the treatment of refractory.
Safety and tolerability of pegylated interferon pegifn. Safety and tolerability of pegylated interferon peg ifn alfa2a in hiv infected people the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In studies submitted to the fda, 868 hcvhiv coinfected patients were randomized to receive peginterferon alfa2a plus placebo, peginterferon alfa2a plus ribavirin, or interferon alfa2a plus. An update on the treatment of hemangiomas in children with. Here a pilot study is reported in which 10 patients with exudative agerelated macular degeneration armd have been treated with a course of interferon injections. In some cases, health care professionals may use the trade names intron a, roferona or other names such as ifnalpha and alpha interferon when referring to the generic drug name interferon alfa. Interferon alfa is one antiangiogenic agent thought to function by inhibiting the migration and proliferation of vascular endothelial cells.
Interferon alfa2b is indicated for the treatment of hairy. Intron a interferon alfa2b uses, side effects, dosage. Interferon associated retinopathy british journal of ophthalmology. Interferon alpha2a for subfoveal n eovascularization in agerelated macular degeneration lon s. Corneal neovascularization cnv is a visionthreatening condition arising from various corneal diseases. Clinical sciences longterm efficacy and safety of low. Interferon alfa 2a is in the fda pregnancy category c. Method of treatment of macular degeneration oculex. Comparison of the effects of subconjunctival injections of. Interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. Decrease or loss of vision, retinopathy including macular edema, retinal artery or vein thrombosis, retinal hemorrhage and cotton wool spots, optic neuritis. Before you use interferon alfa 2b for the first time, you or the person who will be giving the injections should read the manufacturers information for the patient that comes with it.
They found no evidence of improved visual acuity with potential harm. Interferon alfa2a, recombinant injection drug information. Antiangiogenic therapy is a new approach to the treatment of neovascular agerelated macular degeneration. Interferon alpha2a treatment for postuveitic refractory macular. Interferon alfa2a in the treatment of exudative agerelated. The wet form of agerelated macular degeneration amd affects approximately 250,000 americans per year. Interferon injections may resolve ocular surface squamous. Interferon alfa2a is ineffective for patients with choroidal. May 17, 2004 the wet form of agerelated macular degeneration amd affects approximately 250,000 americans per year. Interventions each patient received daily subcutaneous injections of interferon alfa 2a to a target dose of 3 million um 2 of body surface area for a minimum of 4 months. Purpose to evaluate the efficacy of interferon ifn alfa2a for the treatment of long lasting refractory cystoid macular edema cme in noninfectious uveitis. Interferon alfa2a should be discontinued if patient develops persistent or unexplained pulmonary infiltrates or pulmonary function impairment.
Interferon alfa2a is ineffective for patients with choroidal neovascularization secondary to agerelated macular degeneration. Request pdf successful treatment of chronic pseudophakic macular edema irvine gass syndrome with interferon alpha. Interferons caused many longterm side effects partly because of this long treatment time. Pegylated interferon alfa2a is an alfa interferon that is fda approved for the treatment of chronic hepatitis c and chronic hepatitis b. Interferons are proteins released in the body in response to viral infections.
In study 5 n630, subjects received either roferona interferon alfa 2a 3 miu three times a week, pegasys 5 mcg once weekly or pegasys 180 mcg once weekly. Typical ocular lesions include cotton wool spots and retinal haemorrhages at the posterior. Patients were assigned interferon alfa2b, colchicine, and benzathine penicillin, or colchicine and benzathine. Interferons are substances produced by cells in the body to help fight infections and tumors. Sep 10, 2011 interferon injections resolved tumors in patients with primary or recurrent ocular surface squamous neoplasia, with only one relapse reported among 15 eyes after extended followup, according to a. To perform a prospective pilot study to evaluate interferon alfa 2a ifn alfa 2a for the treatment of refractory cystoid macular edema cme in endogenous uveitis. Roferona interferon alfa2a, recombinant is indicated for the treatment of chronic hepatitis c and hairy cell leukemia in patients 18 years of age or older. Successful treatment of chronic pseudophakic macular edema. To report the effect of subtenon injections of natural leukocyte interferon. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine.
Peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain. Peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy. Interferon alfa2b for intramuscular, subcutaneous, intralesional, or intravenous injection intron a is a purified sterile recombinant interferon product. Human recombinant interferon alfa2a for the treatment of behcets. Peginterferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Roferona interferon alfa 2a, recombinant is a sterile protein product for use by injection. A computergenerated, random numbers list was used for allocation of treatment groups. However, the absence of a clear doseresponse relationship raises the possibility that the observed differences result. Local injections of interferon are used to treat condylomata acuminata. All patients were treated with subcutaneous injections of 6 million international units of interferon alpha2a, 3 times a week, for an average period of 10 months. Interferon alpha is used for treating peyronies patients because it reduces the production of collagen in the plaque. Based on its antiinflammatory, antiproliferative, and antiangiogenic effects, systemic and subtenon interferon alpha has been employed in the treatment of a wide range of posterior segment problems.
It is produced by mammalian cells, while interferon beta1b is produced in modified e. Do not use interferon alfa 2b with ribavirin rebetol if you are pregnant. Interferon beta1a also interferon beta 1alpha is a cytokine in the interferon family used to treat multiple sclerosis ms. Interferons are important for fighting viruses in the body, for regulating reproduction of cells, and for regulating the immune system. Interferon has many side effects which often limit the dose and duration of therapy. The peripheral neuropathy and vision of the right eye improved, but the vision of the left eye worsened after stopping interferon. Food and drug administration fda for the treatment of chronic hepatitis b virus infection and chronic hepatitis c virus infection. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to. Interferon alfa 2a, interferon alfa 2b, peginterferon beta1a, and interferon beta1b may increase blood levels of zidovudine azt, retrovir.
Injections, subcutaneous subject areas on research. Roferona interferon alfa2a, recombinant is a sterile protein product for use by injection. Common questions and answers about interferon alfa 2b intron a. Interferon alfa2a for the treatment of chronic refractory cystoid. Subtenon injection of natural leukocyte interferon. Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol. To determine the efficacy of pegylated interferon alfa2a in the treatment of refractory inflammatory cystoid macular edema cmemethods. Interferon alfa for the treatment of neovascular age. After that, you can inject interferon alfa 2b yourself or have a friend or relative give you the injections.
Interferons are classified as alpha, beta and gamma interferons. B retinal vascular occlusion before interferon alfa2a treatment, at the 8month followup. Roferona is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli bacterium containing dna that codes for the human protein. Interferon alfa2a is ineffective for patients with choroidal neovascularization secondary to agerelated macular.
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